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In conclusion, the wholesale classification of calcium carbonate is an important aspect of the calcium carbonate industry that helps categorize and differentiate the different grades of calcium carbonate based on their quality and intended use. Whether it is for pharmaceutical, food, industrial, or agricultural applications, there is a suitable grade of calcium carbonate available to meet the specific requirements of each industry. This classification system ensures that the right grade of calcium carbonate is used for the right application, ultimately leading to better quality products and improved performance.

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The global Lithopone market is highly consolidated and a major bulk of Lithopone is produced in China. Some of the major Lithopone producers include Anhui Union Titanium Enterprise Co. Ltd., Fengchen Group Co. Ltd., Henan Premtec Enterprise Corporation, Langfang Pairs Horses Chemical Co. Ltd., Natural Pigments Inc., Noah Technologies Corporation, Titanos Group, VB Technochemicals SA, Venator Materials PLC, and ZhengZhou Sino Chemical Products Co. Ltd.

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Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

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